BackgroundCommunity engagement within biomedical research is broadly defined as a collaborative relationship between a research team and a group of individuals targeted for research. A Community Advisory Board is one mechanism of engaging the community. Within genomics research CABs may be particularly relevant due to the potential implications of research findings drawn from individual participants on the larger communities they represent. Within such research, CABs seek to meet instrumental goals such as protecting research participants and their community from research-related risks, (...) as well as intrinsic goals such as promoting the respect of participants and their community. However, successful community engagement depends on the degree to which CABs legitimately represent and engage with communities targeted for research. Currently, there is little literature describing the use of CABs in genomics research taking place in developing countries, and even less in the field of genomics research relating to mental illness. The aim of this article is to describe and consider the contributions made by a researcher-driven, population-specific CAB in a genomics of schizophrenia research project taking place in South Africa, from the perspective of the research team.DiscussionFour broad discussion topics emerged during the CAB meetings namely: 1) informed consent procedures, 2) recruitment strategies, 3) patient illness beliefs and stigma experiences, and 4) specific ethical concerns relating to the project. The authors consider these discussions in terms of their contributions to instrumental and intrinsic goals of community engagement.SummaryThe CAB gave valuable input on the consent processes and materials, recruitment strategies and suggested ways of minimizing the potential for stigma and discrimination. All of these contributions were of an instrumental nature, and helped improve the way in which the research took place. In addition, and perhaps more importantly, the CAB made a unique and important contribution relating to intrinsic functions such as promoting the respect and dignity of research participants and their community. This was particularly evident in ensuring sensitivity and respect of the community’s traditional beliefs about schizophrenia and its treatment, and in this way promoting a respectful relationship between the research team and the participants. (shrink)

Cell line immortalisation is a growing component of African genomics research and biobanking. However, little is known about the factors influencing consent to cell line creation and immortalisation in African research settings. We contribute to addressing this gap by exploring three questions in a sample of Xhosa participants recruited for a South African psychiatric genomics study: First, what proportion of participants consented to cell line storage? Second, what were predictors of this consent? Third, what questions were raised by participants during (...) this consent process? 760 Xhose people with schizophrenia and 760 controls were matched to sex, age, level of education and recruitment region. We used descriptive statistics to determine the proportion of participants who consented to cell line creation and immortalization. Logistic regression methods were used to examine the predictors of consent. Reflections from study recruiters were elicited and discussed to identify key questions raised by participants about consent. Approximately 40% of participants consented to cell line storage. The recruiter who sought consent was a strong predictor of participant’s consent. Participants recruited from the South African Eastern Cape, and older participants, were more likely to consent; both these groups were more likely to hold traditional Xhosa values. Neither illness nor education were significant predictors of consent. Key questions raised by participants included two broad themes: clarification of what cell immortalisation means, and issues around individual and community benefit. These findings provide guidance on the proportion of participants likely to consent to cell line immortalisation in genomics research in Africa, and reinforce the important and influential role that study recruiters play during seeking of this consent. Our results reinforce the cultural and contextual factors underpinning consent choices, particularly around sharing and reciprocity. Finally, these results provide support for the growing literature challenging the stigmatizing perception that people with severe mental illness are overly vulnerable as a target group for heath research and specifically genomics studies. (shrink)

Williams James’s 1903 election to the National Academy of Sciences has long been understood as well-deserved recognition for his scientific achievement and as evidence that other sciences had begun to accept the “new psychology” as a peer discipline. This note offers a detailed review of the complex course of events that led to James’s election – presented within the context of the Academy’s own history – that illustrates just how a variety of extra-scientific factors had a significant impact on this (...) tribute. It closes with a review of James’s own activities as an Academy member. (shrink)

ABSTRACTThere is surprisingly little empirical evidence supporting theoretical and anecdotal claims regarding the spontaneous production of prototypic facial expressions used in numerous emotion re...

Now, in Emergent Forms of Life and the Anthropological Voice, path-breaking scholar Michael M. J. Fischer moves the discussion to a consideration of the ...

Why do people think that someone living a morally bad life is less happy than someone living a good life? One possibility is that judging whether someone is happy involves not only attributing positive psychological states (i.e., lots of pleasant emotions, few unpleasant emotions, and satisfaction with life) but also forming an evaluative judgment. Another possibility is that moral considerations affect happiness attributions because they tacitly influence attributions of positive psychological states. In two studies, we found strong support for the (...) second hypothesis. Moral considerations only appear to affect happiness attributions when they also affect attributions of positive psychological states. Additionally, both studies supported a hypothesis about why moral judgments have these effects. Specifically, we found that when people judge that someone is living a bad life, they infer that the person is not at peace with themselves. However, when this inference is blocked, moral considerations do not affect attributions of happiness or positive psychological states. In sum, although “happiness” appears to be a purely psychological concept, happiness judgments are sensitive to moral considerations because people often assume that immorality disrupts intrapersonal harmony. (shrink)

Volume 19, Issue 5, May 2019, Page 24-26.

This paper surveys the meaning of aither in Empedocles. Since Aristotle, Empedoclean aither has been generally considered synonymous with air and understood anachronistically in terms of its Aristotelian conception as hot and wet. In critiquing this interpretation, the paper first examines the meaning of “air” in Empedocles, revealing scant and insignificant use of the term. Next, the ancient controversy of Empedocles’ “four roots” is recast from the perspective that aither, rather than air, designates the fourth root. Finally, the nineteen instances (...) of aither in Empedocles’ fragments are considered, revealing a bright and energetic root closely related to the force of life. (shrink)

In November of 2019, the University of California Santa Cruz hosted a 3-day interdisciplinary conference to commemorate the 200th anniversary of the publication of Frankenstein, by Mary Shelley. A panel of senior researchers convened to discuss the impact of the novel on modern discussions of scientific ethics. The panel featured Nandini Bhattacharya, George Blumenthal, Michael M. Chemers, David Haussler, and Jenny Reardon. In the process, the panelists acted as the Institutional Review Board for a proposal from Victor Frankenstein himself.

The essay is a response to an invitation to offer reflections on Richard Lennan’s recent book Tilling the Church for a panel at the annual gathering of the Karl Rahner Society. It situates the work within the distinctive spiritual and intellectual heritage shared by Karl Rahner, Pope Francis, and Lennan’s scholarly community and vocational home at Boston College, namely by reading it through an intentionally Ignatian lens. The review overlays the volume’s ecclesiological explorations with reference to the Spiritual Exercises and (...) to the contours of the current emphasis or re-emergence of the Ignatian tradition on a global stage given the last eleven years and the unique pulpit they provide via the Petrine Office. The piece argues that the adaptability and flexibility of the Ignatian heritage finds profound and lasting resonance with Lennan’s recent project and hopeful agenda. (shrink)

A suspicion about libertarian free will is that freedom is undermined, rather than supported, by the positing of indeterminism within processes of volition. In response, this paper presents a way in which moments of indeterminism can enhance freedom, by showing how such moments can genuinely belong to the agent. The key idea is that of putting the imagination to work in the service of free agency. The suggestion is that indeterministic processes of imaginative generativity can both belong to an agent, (...) and provide a ground for claims of freedom. In contrast to Robert Kane’s libertarian proposal of locating critical self-forming actions in special moments of rational choice, freedom-friendly indeterministic moments of self-shaping are instead posited within processes of imaginative generativity in which our future possibilities are imagined. This incompatibilist alternative to traditional libertarianism is briefly compared to Mele’s modest libertarianism, and defended against a selection of likely criticisms. (shrink)

Previous research shows that students often do not read informed consent forms to understand their rights. Four hundred fifty-eight students participated in an advertised temperament study that actually measured whether they noticed a manipulation within the consent form. Answering five questions about the form raised the percentage of students noticing the manipulation in multiple settings; however, overall rates were low. Fewer than 10% of ethnic minority students noticed the manipulation. If the goal of consent forms in higher education remains an (...) informed decision, these results indicate the need for increased interaction within the consent process. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume's Theory of Belief Michael M. Gorman Belief is a key concept in Hume's philosophy, and yet Hume's statements aboutbeliefappear to be hopelesslyinconsistent.1 Various solutions have been offered, from saying that Hume is incorrigibly confused to saying that his theory ofbeliefchanged over the course of his career. This article will focus on the question ofthe nature ofbelief and show that Hume's theory is in fact consistent. In sections (...) 1 and 2, I will separate those passages where Hume discusses the nature of beUeffrom those where he discusses other questions. In sections 3-6, 1 will examine his theory ofthe nature ofbelief. Finally, in section 7, 1 will briefly look at his theories on other questions concerning belief. 1.Hume's statements about belief can be divided into at least nine different categories. Hume says that a beliefis: 1.an idea conceived in a certain manner (e.g., E 49, T 96); 2.that certain manner ofconception itself(e.g., E 49, T 97); 3.an idea that feels a certain way (e.g., E 48, T 103); 4.that certain feeling itself(e.g., E 49, T 624, 629); 5.an idea that has a great influence on the mind (e.g, T 118-20); 6.an act ofmind rendering realities influential on the mind (e.g., E 49, T 629); 7.a lively idea related to an impression (e.g., T 96); 8.a lively manner of conceiving an idea, which manner arises from an impression (e.g., E 50); 9.something that makes ideas forceful and vivacious (e.g., T 101, 627). If one were in a really bad mood, one could probably split Hume's formulations into even more categories.2 2.One solution wouldbe to saythat Hume ishopelessly confused.3 This is not accurate, however. The first thingtobe done is to notice thatonly the statements belonging to the first four categories are actually answers to the question, What is the nature of beUef? Hume tells us that abeUefis: an ideaconceived in acertainmanner, theverymanner ofconception ofsuch an idea, an idea thatfeels a certain way, thevery feeling of such an idea. To explicate Hume's theory of the nature of Volume XLX Number 1 89 MICHAEL M. GORMAN beUef, I will show that the second formulation is a poor version ofthe first and that the fourth formulation is a poor version ofthe third—in other words, that there are reallyonlytwo theorieshere, notfour. Then I will reconcile these two theories. As for Hume's discussion ofother questions concerning belief, the statementsin the fifth and sixth categories address the question, What does à belief do? Those in the seventh and eighth categories take for granted the statements in the first and second categories respectively and address the further question, What causes beliefs? Those in the ninth category are probably cases of bad writing. All these will be examined in section 7. 3. Let us look at the texts that fit into the first and second categories listed in section 1. These express what can be called Hume's "manner-of-conception theory" (MCT). First, Hume says that a belief is a certain kind ofidea, namely an idea conceived in a certain manner. He describes this manner ofconception by saying that such an idea is conceived with a high degree of force and vivacity, liveliness, and so forth. This analysis rests on Hume's distinction between the content of an idea and the manner in which the idea is conceived. [A]s 'tis certain there is a great difference betwixt the simple conception ofthe existence ofan object, and the beliefofit, and as this difference lies not in the parts or composition of the idea, which we conceive; it follows, that it must lie in the manner, in which we conceive it. (T 94-95) One can believe that something is the case, or one can simply conceive ofits being the case without assenting to it. In both cases, Hume says, the content ofthe idea must be the same. Otherwise, both making up one's mind and disagreeingwith someone wouldbe impossible: making up one's mind would be a transition from thinking about one thing to thinking about... (shrink)

Genome Canada has funded a research project to evaluate the usefulness of different forms of ethical analysis for assessing the moral weight of public opinion in the governance of genomics. This paper will describe a role of public consultation for ethical analysis and a contribution of ethical analysis to public consultation and the governance of genomics/biotechnology. Public consultation increases the robustness of ethical analysis with a more diverse and rich accounts experiences. Consultation must be carefully and respectfully designed to generate (...) sufficiently diverse and rich accounts of moral experiences. Since dominant groupstend to define ethical or policy issues in a manner that excludes some interests or perspectives, it is important to identify the range of interests that diverse publics hold before defining the issue and scope of a consultation. Similarly, a heavy policy focus and pressures to commercialize products risk oversimplification of the discussion and the premature foreclosure of ethical dialogue. Consequently, a significant contribution of ethical dialogue strengthened by social analysis is to consider the context and non-policy use of power to govern genomics and to sustain social debate on enduring ethical issues. (shrink)

This volume is a newly revised and updated edition of _Evolution and Consciousness_ (Brill, 2019) and provides a comprehensive and accessible introduction to the emerging concept of the evolution of consciousness. It presents an overarching model that moves us to a new level of meaning and understanding of our place in the world.

In this article, I examine Thomas Aquinas's teaching on the light of glory (lumen gloriae), and attempt to resolve several problems that arise within this teaching.

Phenomenologists or Continental thinkers argue for the subject-object continuum. For phenomenology, subjectivity is _of_ the object, and object is _for_ the subject. This book applies that continuum to the holistic foundations of work or specialization. The author devotes a chapter to each of eight cultural applications of the subject-object continuum. Chapter One examines the specialist-generalist continuum meaning specialization _for_ general education. That continuum comprises the framework for the remaining seven chapters. Those seven include production _for_ community, design _for_ user, automation (...) _for_ user, computing _for_ society, taxation _for_ society, information _for_ manufacturing, and procedure _for _goal. These eight applications constitute the basis for a core curriculum. The core curriculum gives holistic meaning, order, or cosmos to all jobs and to all people. Cosmos is a Greek word meaning humanistic-scientific order, irreducible to physics. The core curriculum is fundamental cosmology. Each of the eight continuities follow in a logical, systematic manner from the analytic-subjective continuum meaning object _for_ subjectivity. Phenomenology of education can become the human basis of a promising holistic logic, bringing together analytic and existential themes. (shrink)

The fair innings argument (FIA) is frequently put forward as a justification for denying elderly patients treatment when they are in competition with younger patients and resources are scarce. In this paper I will examine some arguments that are used to support the FIA. My conclusion will be that they do not stand up to scrutiny and therefore, the FIA should not be used to justify the denial of treatment to elderly patients, or to support rationing of health care by (...) age.There are six issues arising out of the FIA which are to be addressed. First, the implication that there is such a thing as a fair share of life. Second, whether it makes sense to talk of a fair share of resources in the context of health care and the FIA. Third, that 'fairness' is usually only mentioned with regard to the length of a person's life, and not to any other aspect of it. Fourth, if it is sensible to discuss the merits of the FIA without taking account of the 'all other things being equal' argument. Fifth, the difference between what is unfair and what is unfortunate. Finally, that it is tragic if a young person dies, but only unfortunate if an elderly person does. (shrink)

In diesem Buch werden Aspekte der Aussagenlogik und der Prädikaten­ logik der ersten Stufe behandelt. Eine Mathematisierung und Kalkü­ lisierung der Logik kann natürlich ganz verschieden ausfallen, je nach dem, von welchen Motiven man sich primär leiten läßt. Wir stellen drei Gesichtspunkte, die uns auch als die wesentlichsten erscheinen, in den Vordergrund: Die Formalisierung des Wahrheits­ begriffes, die Formalisierung des Beweisbarkeitsbegriffes und das Problem des Suchens nach Beweisen. Diese drei Aspekte führen zu drei verschiedenen Arten von Kalkülen. Die Betonung des (...) Wahrheitsbegriffes führte auf die untersuchung der Hilberttypkalküle von einem Standpunkt, wie er etwa auch im Buch von Rasiowa-Sikorski [Ra-Si] eingenommen wird. Hierbei wurde besonderen Wert auf die algebraischen Techniken gelegt, denn die Natur der Vollständigkeitsbeweise in diesen Kalkülen läßt sich u. E. eigentlich nur algebraisch verstehen. Etwas überspitzt könnte man formulieren, daß die Vollständigkeitsbeweise in Hilberttypkal­ külen Korollare zu Betrachtungen über Kongruenzrelationen in ge­ wissen Boole'schen Algebren sind. Bei den modelltheoretischen Be­ trachtungen haben wir uns kurz ge faßt und nur einige grundlegende Begriffe vorgestellt. (shrink)

In Michael Stingl argues that the legalization of euthanasia can be made reasonable social policy only in the context of healthcare reform to deliver primary- and community-based care. Stingl accepts that euthanasia and that includes not only pain, but He is not worried The failure of the healthcare system to adequately respond to the needs of people who are suffering with chronic or terminal conditions may lead competent people to elect euthanasia. Stingl argues that it is the institutionalization of (...) care for dying people that reduces their ability to find meaning in prolonged life, and thereby makes it more attractive to consider ending one's life sooner. Options such as palliative care at home that significantly improve quality of life and make euthanasia less attractive are currently only available to those who can privately subsidize healthcare services. If an emphasis is placed on community-based initiatives and well-supported self-help, then there would be less inequality of healthcare and the voluntariness of choices, including euthanasia, would be more equal for all people under the healthcare system. (shrink)

The archive is the place for the storage of documents and records. With the emergence of the modern state, it became the storehouse for the material from which national memories were constructed. Archives also housed the proliferation of files and case histories as populations were subjected to disciplinary power and surveillance. Behind all scholarly research stands the archive. The ultimate plausibility of a piece of research depends on the grounds, the sources, from which the account is extracted and compiled. An (...) expanding and unstable globalizing archive presents particular problems for classifying and legitimating knowledge. Increasingly the boundaries between the archive and everyday life become blurred through digital recording and storage technologies. Not only does the volume of recordable archive material increase dramatically, but the volume of material seen worthy of archiving increases too, as the criteria of what can, or should be, archived expands. Life increasingly becomes lived in the shadow of the archive. (shrink)